交联聚乙烯电缆绝缘老化超低频介损试验及评价规程研究

本文基于通过检测电缆超低频介损值确定电缆老化程度的基本原理,结合某地实测得到的多组数据,通过国际规程IEEE 400.2—2013进行初步判断,分析处于不同状态下的电缆介损值的变化规律及其原因,并得出该规程仅适用于没有局部劣化的电缆.此外,由于我国电缆制造材料、结构和生产工艺与国外产品存在差异,采用国际规程判断电缆老化程度有时会变得不准确.为解决此类问题,本文建立更加全面的判据体系,给出最优判断阈值的确定方法,并对该地区实测得到的数据进行拟合,得到更加准确的分级判断阈值.此方法可为建立符合我国电缆实际情况的评价规程提供参考.     

A Dual Inhibitor of DYRK1A and GSK3β for β-Cell Proliferation: Aminopyrazine Derivative GNF4877

Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell mass are less developed. Promoting β-cell proliferation with low-molecular-weight inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) offers the potential to treat diabetes with oral therapies by restoring β-cell mass, insulin content and glycemic control. GNF4877, a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) was previously reported to induce primary human β-cell proliferation in vitro and in vivo. Herein, we describe the lead optimization that lead to the identification of GNF4877 from an aminopyrazine hit identified in a phenotypic high-throughput screening campaign measuring β-cell proliferation.     

轧制与退火对T9S钛合金板材组织与性能的影响

研究了轧制变形量及退火温度对T9S钛合金板材显微组织和室温力学性能的影响。结果表明:增加成品轧制变形量,板材组织破碎更充分,退火后形成等轴α相、拉长α相和晶间β相组织形貌,变形流线比较明显,板材室温强度和硬度升高,伸长率降低,弹性模量增加。随着退火温度升高,板材室温强度和硬度逐渐降低,伸长率逐渐提高,横向弹性模量逐渐减小,纵向弹性模量先增加后减小。经(750~790) ℃×45 min空冷退火处理后的板材可以获得较好的强度和塑性的匹配。     

诺氟沙星片在中国健康受试者空腹和餐后状态下生物等效性研究#br#

目的：采用随机、开放、两周期、自身交叉、单次给药试验设计比较浙江医药股份有限公司新昌制药厂生产的诺氟沙星片与原研产品BACCIDAL在中国健康人体中的生物利用度，并评价两种制剂的生物等效性。方法：分别在空腹和餐后条件下，健康受试者随机交叉单剂量口服诺氟沙星片受试制剂或参比制剂100 mg，采用液相色谱-质谱串联（LC-MS/MS）法测定受试者服药前后不同时间点血浆内药物浓度，采用WinNonlin 7.0软件计算主要药代动力学参数，并评价两种制剂的生物等效性。结果：空腹试验共有28例受试者入组并完成试验，诺氟沙星受试制剂与参比制剂的Cmax分别为（607.62±125.24）ng/mL和（552.01±134.11）ng/mL；AUC0-t分别为（2 551.66±509.08）ng·mL-1·h和（2 429.98±460.47）ng·mL-1·h；AUC0-∞分别为（2 675.40±523.04）ng·mL-1·h和（2 557.68±485.43）ng·mL-1·h；t1/2分别为（6.07±0.69）h和（6.18±0.92）h；两种制剂的Cmax、AUC0-t和AUC0-∞几何均值比的90%置信区间分别为101.45%～121.94%、98.96%～111.27%、98.82%～110.76%。餐后试验共有28例受试者入组并完成试验，诺氟沙星受试制剂与参比制剂的Cmax分别为：（256.54±58.87）ng/mL和（300.80±94.67）ng/mL；AUC0-t分别为（1 314.74±349.92）ng·mL-1·h和（1 278.60±314.77）ng·mL-1·h；AUC0-∞分别为（1 413.73±361.98）ng·mL-1·h和（1 374.98±321.62）ng·mL-1·h；t1/2分别为（6.66±1.23）h和（6.66±1.34）h；两种制剂的Cmax、AUC0-t和AUC0-∞几何均值比的90%置信区间分别为81.42%～93.56%、99.61%～105.58%、99.80%～105.21%。结论：浙江医药股份有限公司新昌制药厂生产的诺氟沙星片与原研产品BACCIDAL在中国健康受试者空腹和餐后服用的状态下等效且安全性良好，临床上可以替换使用。     

microRNA在亨廷顿病中的研究进展

亨廷顿病(Huntington's disease, HD)是神经退行性疾病(neurodegenerative disorders)中一种单基因遗传病,由亨廷顿基因(the huntingtin gene, HTT)第一个外显子中的CAG三核苷酸序列重复扩增引起,尚无法治愈。HTT编码的蛋白产物被称为亨廷顿蛋白(Huntingtin protein, Htt)。突变亨廷顿蛋白(mutated huntingtin protein, mHtt)容易形成聚集体,具有毒性,导致一系列细胞学异常和神经元功能障碍。microRNA(miRNA)在基因转录后水平调控中起重要作用,其表达的改变与HD病理过程有关,成为治疗HD的潜在生物标志物。近年来,对一些特定miRNA在HD中调控机制及靶基因预测方面的研究可为HD提供潜在的治疗方法。本文就miRNA在HD中的相关研究进展进行综述。     

铁尾矿砂力学特性及再生利用研究进展

铁尾矿砂的储量日趋增加,要减小铁尾矿坝的风险、提高铁尾矿砂的利用率,须明确铁尾矿砂的力学特性.通过对铁尾矿砂静力特性及动力特性的分析发现,尾矿砂的粒径分布是决定尾矿坝稳定及铁尾矿砂再生利用的主要因素之一,细粒含量、干密度、含水率等因素对铁尾矿砂动力特性有一定影响.再生利用铁尾矿砂的主要方式是将铁尾矿砂混凝土、改性铁尾矿砂用作工程材料,水泥、石灰、纤维是改性铁尾矿砂的主要材料.最后指出需进一步研究新型材料取代传统改性材料改善铁尾矿砂的力学特性,从而提高资源利用率.     

Densification mechanism during reactive hot pressing of B4C-ZrO2 mixtures

The densification behaviors of pure B₄C and B₄C-ZrO₂ mixtures were compared during hot pressing. The results showed that in-situ formed ZrB₂ effectively enhanced the densification process of B₄C-ZrO₂ mixtures, more significantly during the intermediate stage. Within the relative density ranging from 0.75 to 0.90, the B₄C-15?wt%ZrO₂ mixture (B15Z) achieved the maximum densification rate as twice much as that of pure B₄C. The stress exponent n>3 indicated plastic deformation was the dominant densification mechanism of B15Z. The viscosities of plastic flow were evaluated using Murray-Rodger-William equation and the viscosity of B15Z was only a quarter of that in pure B₄C. The sintering activation energy was calculated to be 305.9?kJ/mol for pure B₄C and 197?kJ/mol for B15Z, respectively. It was proposed that the lower viscosity of plastic flow and activation energy accelerated the sliding and propagating motions of plastic flow, by which underlain the enhanced densification behaviors of B₄C-ZrO₂ mixtures.     

利用煤矸石制备泡沫陶瓷的研究

以煤矸石为研究对象,利用XRD和XRF技术,研究了煤矸石的矿物组成和化学成分.以煤矸石和低品位铝矾土为主要原料,长石作为助熔剂,振实成型后在1 200℃下焙烧成泡沫陶瓷.结果 表明,当原料中煤矸石的含量为61wt％时,所制备泡沫陶瓷的基本性能为:导热系数0.059 W/(m·K)、体积密度118.6 kg/m3、体积吸水率1.3％、抗压强度1.3 MPa、抗折强度1.4 MPa.利用煤矸石制备泡沫陶瓷,为煤矸石综合利用提供了一条可行的途径.     

The Gut Microbiota: A Potential Gateway to Improved Health Outcomes in Breast Cancer Treatment and Survivorship

Breast cancer is the most frequently diagnosed cancer in women worldwide. The disease and its treatments exert profound effects on an individual’s physical and mental health. There are many factors that impact an individual’s risk of developing breast cancer, their response to treatments, and their risk of recurrence. The community of microorganisms inhabiting the gastrointestinal tract, the gut microbiota, affects human health through metabolic, neural, and endocrine signaling, and immune activity. It is through these mechanisms that the gut microbiota appears to influence breast cancer risk, response to treatment, and recurrence. A disrupted gut microbiota or state of ‘dysbiosis’ can contribute to a biological environment associated with higher risk for cancer development as well as contribute to negative treatment side-effects. Many cancer treatments have been shown to shift the gut microbiota toward dysbiosis; however, the microbiota can also be positively manipulated through diet, prebiotic and probiotic supplementation, and exercise. The objective of this review is to provide an overview of the current understanding of the relationship between the gut microbiota and breast cancer and to highlight potential strategies for modulation of the gut microbiota that could lead to improved clinical outcomes and overall health in this population.     

净水水处理剂中有害杂质在水中残留物分析与风险评估

与欧盟和美国标准相比,我国硫酸铝和硫酸铵标准缺少对水处理剂中有害杂质镍、锑、硒、银、吡啶、氰化物、六价铬的检测;次氯酸钠缺少对水处理剂中有害杂质汞、铬、镉、铁、镍、锑、硒、银、六价铬的检测。结合某市2019年上半年13个水厂出厂水和原水的检测数据,剔除了5项始终低于检出限的有害杂质指标,以及2项出厂水浓度低于原水浓度的有害杂质指标。建议该市硫酸铝和硫酸铵的检测项目可以在原有国标基础上增加锑、硒;次氯酸钠可以增加汞、锑、硒。